Endocrine Abstracts

Introduction: Spontaneous fertility in Turner syndrome (TS) is rare, due to low or absent ovarian reserve. A greater number of ovarian follicules is present in the cases of gonadal mosaicism, although the accelerated pace of apoptosis remains. Thus, the early referral to reproductive counseling is advisable, ideally soon after diagnosis. The criopreservation of oocytes is one of the options for fertility preservation. The authors present a series of 7 patients with TS admitted...

Introduction: Neuroglucopenic hypoglycaemia might be an underestimated threat of bariatric surgery, as Roux-en-Y gastric bypass (RYBG) or gastric sleeve. We aimed to evaluate glucose variability after bariatric surgery by continuous glucose monitoring (CGM) in a real-life setting.Methods: CGM was used in twelve patients with clinical suspicion of hypoglycaemia after undergoing bariatric surgery (RYBG or sleeve), during seven days. CGM was through using i...

Introduction: The prevalence of obesity has increased, reaching epidemic proportions. Framingham and REGICOR scales predict the likelihood of developing a coronary event in the next 10 years. The aim of this study was to assess the concordance of these scales in the stratification of cardiovascular risk (CVR) in a cohort of patients with morbid obesity.Methods: We designed a cross-sectional study in a sample of patients with morbid obesity evaluated from...

Introduction: Craniopharyngiomas are rare epithelial tumors of the sellar and parasellar region, with high survival rates but with frequent tumor recurrence or persistence.Methods: Information collection from clinical records and review of the epidemiology, diagnosis, treatment and follow-up of patients with diagnosis of craniopharyngioma followed in an Endocrinology Department between 1980 and 2015. Statistical analysis using SPSS v. 22.0.<p class="...

Introduction and objectives: Testosterone therapy (TT) in female-to-male transsexuals (FMT) usually causes cessation of menses within the first few months. However the changes in the hormonal profile are not well known. We set out to analyze the hormonal changes and menstrual evolution in a cohort of FMT who began TT.Methodology: Retrospective observational study with no control group in a cohort of 34 FMT patients who started TT following a standard pro...

Background: Amiodarone is an antiarrhytmic drug used mainly in atrial fibrillation. Amiodarone-induced thyrotoxicosis (AIT) is less common than hypothyroidism, but it represents a true therapeutic challenge. AIT can be due iodine load (type 1) or a destructive thyroiditis (type 2).Methods: Retrospective study of patients with AIT, diagnosed between 2010 and 2015, in a central hospital. We reviewed medical records regarding age, gender, amiodarone therapy...

Background: Fine-needle aspiration (FNA) is an important test for triaging patients with thyroid nodules and differentiating benign from malignant disease. According to Bethesda System Classification, the rate of AUS/FLUS is between 3–6% of all FNA. The malignancy risk is of 5–15%. TSH levels might be associated to the likelihood of malignancy in thyroid nodules according to some studies. Our aim was to establish a possible correlation between TSH level and malignanc...

Context: Insulin resistance is an important component of polycystic ovary syndrome (PCOS). Local cytokine production in adipose tissue increases local insulin resistance. The effect of testosterone on local adipose tissue cytokine production has not been explored thoroughly.Aim: To evaluate cytokine expression in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from PCOS and control women and evaluate the response to testosterone on th...

Introduction: 25-hydroxyvitamin D (25(OH)D3) deficiency has been associated with diabetes and obesity. However, the mechanisms underlying these relationships are not completely understood. Vitamin D receptor (VDR) is expressed in adipose tissue; it has been reported a higher expression in obese patients than in lean subjects, suggesting a differential vitamin D dynamics in adipose tissue according to the obesity degree. In addition, 1, 25-dihydroxyvitamin D3 (1,25(OH)2D3) is a...

Introduction: In preliminary results of our group, we detected an association between the mean nocturnal blood pressure and development microvascular complications. The objective was to evaluate possible nocturnal blood pressure cut off points in relation to the development or progression of retinopathy, microalbuminuria and arterial hypertension in type 1 diabetic patients.Methods: We designed a prospective observational study of 85 patients, clinically...